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Войти в исследования Schmerz (Berlin, Germany) · 2026
[Postoperative pain and sex/gender-current findings of the past decade].
Аннотация на английскомСтатьяScoping ReviewНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Floren Stefan, Segelcke Daniel, Pogatzki-Zahn Esther
Аннотация
BACKGROUND: Sex and gender affect pain perception but their role in postoperative pain remains unclear and is not addressed in current guidelines.
OBJECTIVES: This scoping review summarizes evidence from the past ten years on sex-related differences in postoperative pain (patient-reported outcome (PRO), opioid consumption) and evaluates their relevance.
MATERIALS AND METHODS: Systematic search in Medline® (March 2015-18 August 2025); 106 studies included.
PRIMARY OUTCOME: acute pain intensity (≤ 3 weeks).
SECONDARY OUTCOMES: subacute/chronic postsurgical pain and opioid use.
RESULTS: Of the 106 studies included, 44 covered acute pain. In most of them women reported higher pain intensity-particularly after thoracic surgery and orthopedic procedures; several analyses confirmed female sex as an independent predictor for postoperative pain. Studies related to subacute pain (5/106) reported slightly higher pain intensity ratings in women, and the results in chronic pain studies (44/106) were mixed, with more severe pain in women after visceral surgeries. While results for acute opioid consumption (16/106) were heterogeneous, for the long-term postoperative course, studies (9/106) consistently reported a higher persistence of analgesic/opioid use in women.
CONCLUSIONS: Sex is a relevant factor regarding pain-related outcome parameters after surgery, and its impact is influenced by the postoperative timeframe and type of surgery. Further studies with standardized, sex-stratified endpoints are required to enable gender-sensitive patient care.
OBJECTIVES: This scoping review summarizes evidence from the past ten years on sex-related differences in postoperative pain (patient-reported outcome (PRO), opioid consumption) and evaluates their relevance.
MATERIALS AND METHODS: Systematic search in Medline® (March 2015-18 August 2025); 106 studies included.
PRIMARY OUTCOME: acute pain intensity (≤ 3 weeks).
SECONDARY OUTCOMES: subacute/chronic postsurgical pain and opioid use.
RESULTS: Of the 106 studies included, 44 covered acute pain. In most of them women reported higher pain intensity-particularly after thoracic surgery and orthopedic procedures; several analyses confirmed female sex as an independent predictor for postoperative pain. Studies related to subacute pain (5/106) reported slightly higher pain intensity ratings in women, and the results in chronic pain studies (44/106) were mixed, with more severe pain in women after visceral surgeries. While results for acute opioid consumption (16/106) were heterogeneous, for the long-term postoperative course, studies (9/106) consistently reported a higher persistence of analgesic/opioid use in women.
CONCLUSIONS: Sex is a relevant factor regarding pain-related outcome parameters after surgery, and its impact is influenced by the postoperative timeframe and type of surgery. Further studies with standardized, sex-stratified endpoints are required to enable gender-sensitive patient care.