Occupational medicine (Oxford, England) · 2012
Mental health in Alberta grain farmers using pesticides over many years.
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Cherry N, Burstyn I, Beach J, Senthilselvan A
Аннотация
BACKGROUND: Exposure to organophosphates and certain other pesticides has been related to symptoms of mental ill-health. There is particular interest in whether exposure over many years may result in chronic ill-health.
AIMS: To relate lifetime history of pesticide exposure to symptoms and medical records of mental ill-health in elderly grain farmers in Alberta.
METHODS: Two populations of grain farmers were identified for study: cohort A (n = 5986), members of an Alberta farm organization in 1983; cohort B (n = 4781), grain farmers registered with the provincial department of agriculture. In 2002-03 both groups completed a questionnaire on lifetime history of pesticide use, physician diagnosed disease and recent neuropsychological symptoms. Durations of exposure to seven pesticide components were calculated and a factor score extracted from responses to the symptom questionnaire. For a sub-cohort surviving to 2009 medical records for mental ill-health were identified. Records and symptom scores were related to pesticide exposures allowing for confounding.
RESULTS: From cohort A, 1348 and cohort B, 1078 were alive and interviewed (median age 63 years; median duration in farming 40 years): 1371 were linked to the medical records database. Mental ill-health symptom scores were related to duration of exposure to phenoxy compounds (but not to other pesticides) and to mental ill-health in medical records. Those with mental ill-health in hospital discharge records were more likely to have been exposed to phenoxy compounds for ≥35 years.
CONCLUSIONS: The relationship of long-term exposure to phenoxy herbicides and neuropsychiatric symptoms was unexpected but not explained by measured confounders.
AIMS: To relate lifetime history of pesticide exposure to symptoms and medical records of mental ill-health in elderly grain farmers in Alberta.
METHODS: Two populations of grain farmers were identified for study: cohort A (n = 5986), members of an Alberta farm organization in 1983; cohort B (n = 4781), grain farmers registered with the provincial department of agriculture. In 2002-03 both groups completed a questionnaire on lifetime history of pesticide use, physician diagnosed disease and recent neuropsychological symptoms. Durations of exposure to seven pesticide components were calculated and a factor score extracted from responses to the symptom questionnaire. For a sub-cohort surviving to 2009 medical records for mental ill-health were identified. Records and symptom scores were related to pesticide exposures allowing for confounding.
RESULTS: From cohort A, 1348 and cohort B, 1078 were alive and interviewed (median age 63 years; median duration in farming 40 years): 1371 were linked to the medical records database. Mental ill-health symptom scores were related to duration of exposure to phenoxy compounds (but not to other pesticides) and to mental ill-health in medical records. Those with mental ill-health in hospital discharge records were more likely to have been exposed to phenoxy compounds for ≥35 years.
CONCLUSIONS: The relationship of long-term exposure to phenoxy herbicides and neuropsychiatric symptoms was unexpected but not explained by measured confounders.