F&S science · 2026
Stereological assessment of resveratrol's impact on folliculogenesis and sex hormone levels in busulfan-treated rats.
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Nia Negin Rafati, Golbashirzadeh Morteza, Moradzadegan Atousa
Аннотация
OBJECTIVE: To study the stereological effects of resveratrol on folliculogenesis and sex hormone concentrations in busulfan-treated rats.
DESIGN: Experimental animal study.
SUBJECTS: Twenty-four adult female Sprague-Dawley rats.
EXPOSURE: Animals were randomly assigned to 4 groups: control, busulfan (10 mg/kg, single intraperitoneal dose), busulfan plus resveratrol (10 mg/kg), and busulfan plus resveratrol (20 mg/kg). Resveratrol was administered orally for 35 days.
MAIN OUTCOME MEASURES: Serum concentrations of luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone were measured. Ovarian stereological analysis assessed follicle counts and corpus luteum volume.
RESULTS: Busulfan exposure caused severe ovarian damage, including reduced estradiol and progesterone levels, diminished corpus luteum volume, and increased gonadotropins and atretic follicles. High-dose resveratrol (20 mg/kg) partially improved estradiol and progesterone concentrations, increased healthy follicle counts, and enhanced corpus luteum volume, while reducing gonadotropins and atretic follicles (P<.05). These findings indicate attenuation but not complete restoration of busulfan-induced ovarian dysfunction.
CONCLUSION: Busulfan disrupts ovarian function and impairs folliculogenesis. Resveratrol partially mitigates these adverse effects, suggesting its potential as a protective agent against chemotherapy-associated reproductive toxicity.
DESIGN: Experimental animal study.
SUBJECTS: Twenty-four adult female Sprague-Dawley rats.
EXPOSURE: Animals were randomly assigned to 4 groups: control, busulfan (10 mg/kg, single intraperitoneal dose), busulfan plus resveratrol (10 mg/kg), and busulfan plus resveratrol (20 mg/kg). Resveratrol was administered orally for 35 days.
MAIN OUTCOME MEASURES: Serum concentrations of luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone were measured. Ovarian stereological analysis assessed follicle counts and corpus luteum volume.
RESULTS: Busulfan exposure caused severe ovarian damage, including reduced estradiol and progesterone levels, diminished corpus luteum volume, and increased gonadotropins and atretic follicles. High-dose resveratrol (20 mg/kg) partially improved estradiol and progesterone concentrations, increased healthy follicle counts, and enhanced corpus luteum volume, while reducing gonadotropins and atretic follicles (P<.05). These findings indicate attenuation but not complete restoration of busulfan-induced ovarian dysfunction.
CONCLUSION: Busulfan disrupts ovarian function and impairs folliculogenesis. Resveratrol partially mitigates these adverse effects, suggesting its potential as a protective agent against chemotherapy-associated reproductive toxicity.