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Antioxidant and protective effects of methanolic Solanum nigrum leaf extract against CCl4-induced hepatotoxicity and renotoxicity in albino rats.
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Shailabi Taher Issa, Kabbashi Ahmed Saeed, Aldeeb Osama Hussein, Basheer Eman Salah, Gumaa Rehab Aeyad, Younes Ebtihal Jebriel, Mohammed Retaj Fawzi, Ismail Amar Mohamed
Аннотация
BACKGROUND: There is growing interest in natural antioxidants, particularly Solanum nigrum (S. nigrum), because of their potential to protect against oxidative stress-induced organ damage and their intriguing historical use in treating various medical conditions.
AIM: This pioneering study examined the unique antioxidant, hepatoprotective, and renoprotective effects of S. nigrum methanolic leaf extract on carbon tetrachloride (CCl4)-induced toxicity in albino rats.
METHODS: Thirty albino rats (100-120 g) were used. The 2.2 di-(4-tretoctylphenyl)-1-picrylhydrazyl radical scavenging assay was used to evaluate the antioxidant properties of S. nigrum extract. This study examined the protective effects of 150 and 300 mg/kg leaf extract against CCl4-induced toxicity. Body weight, hematological markers, and kidney and liver function were assessed. Histological analysis of liver and kidney tissue was performed.
RESULTS: The radical scavenging activity of S. nigrum was a remarkable 85.02 ± 0.01 RSA%, compared to 66.83 ± 0.02 RSA% for gallic acid, with IC50 values of 58.3 and 1.22 μg/ml, respectively. Solanum nigrum treatment significantly decreased alanine transaminase and aspartate transaminase activities relative to CCl4-induced toxicity, a finding of significance in pharmacology and toxicology.
CONCLUSION: The S. nigrum methanolic extract has an IC50 value of 58.3 μg/ml, demonstrating potent natural antioxidant properties that mitigate hepatotoxicity and renotoxicity induced by CCl4.
AIM: This pioneering study examined the unique antioxidant, hepatoprotective, and renoprotective effects of S. nigrum methanolic leaf extract on carbon tetrachloride (CCl4)-induced toxicity in albino rats.
METHODS: Thirty albino rats (100-120 g) were used. The 2.2 di-(4-tretoctylphenyl)-1-picrylhydrazyl radical scavenging assay was used to evaluate the antioxidant properties of S. nigrum extract. This study examined the protective effects of 150 and 300 mg/kg leaf extract against CCl4-induced toxicity. Body weight, hematological markers, and kidney and liver function were assessed. Histological analysis of liver and kidney tissue was performed.
RESULTS: The radical scavenging activity of S. nigrum was a remarkable 85.02 ± 0.01 RSA%, compared to 66.83 ± 0.02 RSA% for gallic acid, with IC50 values of 58.3 and 1.22 μg/ml, respectively. Solanum nigrum treatment significantly decreased alanine transaminase and aspartate transaminase activities relative to CCl4-induced toxicity, a finding of significance in pharmacology and toxicology.
CONCLUSION: The S. nigrum methanolic extract has an IC50 value of 58.3 μg/ml, demonstrating potent natural antioxidant properties that mitigate hepatotoxicity and renotoxicity induced by CCl4.