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Войти в исследования Emerging infectious diseases · 2023
Invasive Nocardia Infections across Distinct Geographic Regions, United States.
СтатьяОбзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Gupta Simran, Grant Leah M, Powers Harry R, Kimes Kathryn E, Hamdi Ahmed, Butterfield Richard J, Gea-Banacloche Juan, Vijayvargiya Prakhar, Hata D Jane, Meza Villegas Diana M, Dumitrascu Adrian C, Harris Dana M, Chirila Razvan M, Zhang Nan, Razonable Raymund R, Kusne Shimon, Alvarez Salvador, Vikram Holenarasipur R
Аннотация
We reviewed invasive Nocardia infections in 3 noncontiguous geographic areas in the United States during 2011–2018. Among 268 patients with invasive nocardiosis, 48.2% were from Minnesota, 32.4% from Arizona, and 19.4% from Florida. Predominant species were N. nova complex in Minnesota (33.4%), N. cyriacigeorgica in Arizona (41.4%), and N. brasiliensis in Florida (17.3%). Transplant recipients accounted for 82/268 (30.6%) patients overall: 14 (10.9%) in Minnesota, 35 (40.2%) in Arizona, and 33 (63.5%) in Florida. Manifestations included isolated pulmonary nocardiosis among 73.2% of transplant and 84.4% of non–transplant patients and central nervous system involvement among 12.2% of transplant and 3.2% of non–transplant patients. N. farcinica (20.7%) and N. cyriacigeorgica (19.5%) were the most common isolates among transplant recipients and N. cyriacigeorgica (38.0%), N. nova complex (23.7%), and N. farcinica (16.1%) among non–transplant patients. Overall antimicrobial susceptibilities were similar across the 3 study sites.