Clinical biochemistry · 2025
Improving laboratory stewardship through benchmarking: A focus on thyroid function tests ordering.
СтатьяНазвание и аннотация: Перевод в очереди
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Chan Ka Keung, Kim Suhhyun, Mathias Patrick C, Dickerson Jane, Liao Hsuan-Chieh
Аннотация
OBJECTIVES: Thyroid function tests, particularly thyroid-stimulating hormone (TSH) and free thyroxine (fT4), are among the most frequently ordered laboratory tests. This study evaluates longitudinal trends in thyroid testing utilization, assesses the impact of TSH-first reflex testing, and examines specialty-specific differences in test ordering patterns under the PLUGS (Patient-Centered Laboratory Utilization Guidance Services) benchmarking guidelines.
METHODS: We analyzed TSH and fT4 test volumes from the year 2009 to 2023. A TSH reflex algorithm, which automatically orders fT4 following an abnormal TSH, was implemented in 2016. The metrics were evaluated using the TSH to fT4 ratio (TSH/fT4) and the percentage of fT4 tests associated with abnormal TSH. Specialty-specific differences were assessed by categorizing providers' specialty, comparing benchmark patterns and diagnostic codes.
RESULTS: Both TSH and fT4 testing volume increased significantly from 2009 to 2023. After the implementation of TSH-first reflex algorithm, TSH/fT4 stabilized (∼3.7) and the percentage of fT4 tests associated with abnormal TSH increased significantly from 26 % to 39 %. Providers from primary care demonstrated stronger adherence to the reflex testing, whereas endocrinology and oncology required more tailored approaches.
CONCLUSIONS: This first longitudinal analysis of thyroid testing under the PLUGS benchmark guidelines highlights improved efficiency following reflex test implementation, though specialty-specific differences persist. Consensus-based benchmarks and laboratory stewardship initiatives further enhance test utilization efficiency, optimize workflow, and ensure appropriate thyroid function testing across diverse clinical settings.
METHODS: We analyzed TSH and fT4 test volumes from the year 2009 to 2023. A TSH reflex algorithm, which automatically orders fT4 following an abnormal TSH, was implemented in 2016. The metrics were evaluated using the TSH to fT4 ratio (TSH/fT4) and the percentage of fT4 tests associated with abnormal TSH. Specialty-specific differences were assessed by categorizing providers' specialty, comparing benchmark patterns and diagnostic codes.
RESULTS: Both TSH and fT4 testing volume increased significantly from 2009 to 2023. After the implementation of TSH-first reflex algorithm, TSH/fT4 stabilized (∼3.7) and the percentage of fT4 tests associated with abnormal TSH increased significantly from 26 % to 39 %. Providers from primary care demonstrated stronger adherence to the reflex testing, whereas endocrinology and oncology required more tailored approaches.
CONCLUSIONS: This first longitudinal analysis of thyroid testing under the PLUGS benchmark guidelines highlights improved efficiency following reflex test implementation, though specialty-specific differences persist. Consensus-based benchmarks and laboratory stewardship initiatives further enhance test utilization efficiency, optimize workflow, and ensure appropriate thyroid function testing across diverse clinical settings.