International journal of fertility and menopausal studies · 1993
A comparative study of human chorionic gonadotropin, placebo, and bed rest for women with early threatened abortion.
Клиническое исследованиеСравнительное исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Harrison R F
Аннотация
OBJECTIVE: To compare the effect of hCG therapy with placebo or bed rest in women with threatened abortion.
DESIGN: Random assignment, double-blind.
SETTING: Community hospitals.
PATIENTS AND INTERVENTIONS: Sixty-one women with viable pregnancies under 8 weeks' gestation on admission to hospital were randomly allocated to receive injections of hCG or placebo, or were advised to rest in bed.
MAIN OUTCOME MEASURES: Abortion vs. continuation of pregnancy at 16 weeks' gestation.
RESULTS: Thirty-one aborted: 6/20 on hCG, 10/21 on placebo, 15/20 on bed rest. hCG vs. bed rest, P < .01; placebo vs. bed rest, hCG vs. placebo--not significant. Plasma progesterone: continuing pregnancy > abortion, P < .01; continued with hCG vs. aborted on placebo, P < .001; continued with hCG vs. aborted with bed rest, P < .001. No significant differences in pregnancy/birth complications or infants' birth weight. Female/male ratio was 2:1.
CONCLUSIONS: hCG is significantly better than bed rest.
DESIGN: Random assignment, double-blind.
SETTING: Community hospitals.
PATIENTS AND INTERVENTIONS: Sixty-one women with viable pregnancies under 8 weeks' gestation on admission to hospital were randomly allocated to receive injections of hCG or placebo, or were advised to rest in bed.
MAIN OUTCOME MEASURES: Abortion vs. continuation of pregnancy at 16 weeks' gestation.
RESULTS: Thirty-one aborted: 6/20 on hCG, 10/21 on placebo, 15/20 on bed rest. hCG vs. bed rest, P < .01; placebo vs. bed rest, hCG vs. placebo--not significant. Plasma progesterone: continuing pregnancy > abortion, P < .01; continued with hCG vs. aborted on placebo, P < .001; continued with hCG vs. aborted with bed rest, P < .001. No significant differences in pregnancy/birth complications or infants' birth weight. Female/male ratio was 2:1.
CONCLUSIONS: hCG is significantly better than bed rest.