Intercellular adhesion molecule-1 K469E polymorphism in Korean patients with spontaneous preterm delivery.

OBJECTIVES

To investigate the association between intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism and spontaneous preterm delivery in a Korean population.

METHODS

Genomic DNA was extracted from whole blood from 55 women experiencing preterm labor and 153 multiparous women (control group) with a history of at least 2 term deliveries. DNA samples were analyzed by polymerase chain reaction-restriction fragment length polymorphism.

RESULTS

The spontaneous preterm delivery (SPD) group carried the 469E allele significantly more frequently than those in the control group (odds ratio [OR], 1.62; 95% CI, 1.04-2.53). The EE genotype was significantly associated with increased risk of SPD (OR, 2.84; 95% CI, 1.17-6.89; P = 0.02). Allelic frequencies in women with abnormal C-reactive protein levels (K = 0.48; E = 0.52) were significantly different from frequencies in the controls (K = 0.68; E = 0.32) (P = 0.006).

CONCLUSIONS

ICAM-1 gene K469E polymorphism may be a candidate region and useful predictor of susceptibility to SPD in the Korean population.