Journal of forensic sciences · 2015
The Effects of Dextromethorphan on Driving Performance and the Standardized Field Sobriety Test.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Perry Paul J, Fredriksen Kristian, Chew Stephanie, Ip Eric J, Lopes Ingrid, Doroudgar Shadi, Thomas Kelan
Аннотация
Dextromethorphan (DXM) is abused most commonly among adolescents as a recreational drug to generate a dissociative experience. The objective of the study was to assess driving with and without DXM ingestion. The effects of one-time maximum daily doses of DXM 120 mg versus a guaifenesin 400 mg dose were compared among 40 healthy subjects using a crossover design. Subjects' ability to drive was assessed by their performance in a driving simulator (STISIM® Drive driving simulator software) and by conducting a standardized field sobriety test (SFST) administered 1-h postdrug administration. The one-time dose of DXM 120 mg did not demonstrate driving impairment on the STISIM® Drive driving simulator or increase SFST failures compared to guaifenesin 400 mg. Doses greater than the currently recommended maximum daily dose of 120 mg are necessary to perturb driving behavior.