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DOI 10.1590/s0102-865020190120000001

Медицинская библиотека · Acta cirurgica brasileira · 2020

New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory.

Macêdo Clóvis Ney Pinheiro, Braga Francisco Evanilso Silva, Campelo Ana Paula Bomfim Soares, Diniz Gabriel Maia, Lopes Luiz Gonzaga de França, Kubrusly Marcos, Campelo Marcio Wilker Soares

Оценочное исследованиеСтатьяПеревод в очереди

Аннотация

PURPOSE: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam).

METHODS

Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals.

RESULTS

At the histological examination, all animals (six animals - 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05).

CONCLUSION

Rut-bpy may prevent renal histological changes in rats caused by meloxicam.

Для цитирования: Macêdo Clóvis Ney Pinheiro, Braga Francisco Evanilso Silva, Campelo Ana Paula Bomfim Soares, Diniz Gabriel Maia, Lopes Luiz Gonzaga de França, Kubrusly Marcos, Campelo Marcio Wilker Soares. New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory.. Acta cirurgica brasileira. 2020. DOI: 10.1590/s0102-865020190120000001.

Предметные рубрики MeSH

2,2'-DipyridylAnimalsAnti-Inflammatory Agents, Non-SteroidalFractalsKidney DiseasesMaleMeloxicamNitric Oxide DonorsOrganometallic CompoundsRandom AllocationRats, WistarReproducibility of ResultsRuthenium
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