JHLT open · 2026
Early clinical experience with a phase change material-based temperature-controlled cold-chain system for donor heart preservation.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Han Dong Youb, Kim Kitae, Kim Ah Ram, Hong Jung Ae, Hyun Junho, Lee Sang Eun, Kim Min-Seok, Kim Jae-Joong, Jung Sung-Ho
Аннотация
BACKGROUND: Temperature fluctuations during conventional ice-box static cold storage may contribute to donor heart injury. We evaluated a phase change material (PCM)-based temperature-controlled cold-chain container (VIXELL) in consecutive adult heart transplantations.
METHODS: In a single center, 12 consecutive orthotopic heart transplantations (May-Nov 2025) used VIXELL to maintain 2°C-8°C during ground transport with continuous temperature recording. Severe primary graft dysfunction (PGD) was assessed using International Society for Heart and Lung Transplantation criteria.
RESULTS: In-transit temperatures remained within 2°C-8°C in cases reflecting shorter and longer transport durations within the cohort without freezing or excessive warming. Cold ischemic time was 116.8 ± 59.6 min, and early graft function markers were favorable (peak lactate 6.3 ± 2.8 mmol/L; lactate normalization 13.8 ± 3.7 hours). No severe PGD occurred.
CONCLUSIONS: PCM-based temperature control was feasible and provided stable hypothermia during donor heart transport. Larger comparative studies are warranted.
METHODS: In a single center, 12 consecutive orthotopic heart transplantations (May-Nov 2025) used VIXELL to maintain 2°C-8°C during ground transport with continuous temperature recording. Severe primary graft dysfunction (PGD) was assessed using International Society for Heart and Lung Transplantation criteria.
RESULTS: In-transit temperatures remained within 2°C-8°C in cases reflecting shorter and longer transport durations within the cohort without freezing or excessive warming. Cold ischemic time was 116.8 ± 59.6 min, and early graft function markers were favorable (peak lactate 6.3 ± 2.8 mmol/L; lactate normalization 13.8 ± 3.7 hours). No severe PGD occurred.
CONCLUSIONS: PCM-based temperature control was feasible and provided stable hypothermia during donor heart transport. Larger comparative studies are warranted.