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DOI 10.1038/s41467-024-54595-2

Медицинская библиотека · Nature communications · 2024

Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years.

Neller Michelle A, Ambalathingal George R, Hamad Nada, Sasadeusz Joe, Pearson Rebecca, Holmes-Liew Chien-Li, Singhal Deepak, Tunbridge Matthew, Ng Wei Yang, Sharplin Kirsty, Moore Andrew, Deambrosis David, Soosay-Raj Trisha, McNaughton Peter, Whyte Morag, Fraser Chris, Grigg Andrew, Kliman David, Bajel Ashish, Cummins Katherine, Dowling Mark, Yeoh Zhi Han, Harrison Simon J, Khot Amit, Tan Sarah, Roos Izanne, Koo Ray Mun, Dohrmann Sara, Ritchie David, Wainstein Brynn, McCleary Karen, Nelson Adam, Gardiner Bradley, Inam Shafqat, Badoux Xavier, Ma Kris, Toro Claudia, Hanna Diane, Hughes David, Conyers Rachel, Cole Theresa, Wang Shiqi Stacie, Chee Lynette, Fleming Jacqueline, Irish Ashley, Purtill Duncan, Cooney Julian, Shaw Peter, Tey Siok-Keen, Hunt Stewart, Subramonia Pillai Elango, John George, Ng Michelle, Ramachandran Shanti, Hopkins Peter, Chambers Daniel, Campbell Scott, Francis Ross, Isbel Nicole, Marlton Paula, Reddiex Hilary, Matthews Katherine K, Voogt Meggie, Panikkar Archana, Beagley Leone, Rehan Sweera, Best Shannon, Raju Jyothy, Le Texier Laetitia, Crooks Pauline, Solomon Matthew, Lekieffre Lea, Srihari Sriganesh, Smith Corey, Khanna Rajiv

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Аннотация

Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with "off-the-shelf" allogeneic T cells directed to a combination of Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration's Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder. Adoptive immunotherapy is well tolerated with few adverse effects. Importantly, 46/71 (65%) patients show definitive clinical improvement including reduction in viral load, clinical symptoms and complete resolution of end-organ disease. In addition, seven high-risk patients remain disease free. Based on this long-term encouraging clinical experience, we propose that a dedicated nationally funded centre for anti-viral cellular therapies should be considered to provide T cell therapies for critically ill patients for compassionate use.

Для цитирования: Neller Michelle A, Ambalathingal George R, Hamad Nada, Sasadeusz Joe, Pearson Rebecca, Holmes-Liew Chien-Li, Singhal Deepak, Tunbridge Matthew, Ng Wei Yang, Sharplin Kirsty, Moore Andrew, Deambrosis David, Soosay-Raj Trisha, McNaughton Peter, Whyte Morag, Fraser Chris, Grigg Andrew, Kliman David, Bajel Ashish, Cummins Katherine, Dowling Mark, Yeoh Zhi Han, Harrison Simon J, Khot Amit, Tan Sarah, Roos Izanne, Koo Ray Mun, Dohrmann Sara, Ritchie David, Wainstein Brynn, McCleary Karen, Nelson Adam, Gardiner Bradley, Inam Shafqat, Badoux Xavier, Ma Kris, Toro Claudia, Hanna Diane, Hughes David, Conyers Rachel, Cole Theresa, Wang Shiqi Stacie, Chee Lynette, Fleming Jacqueline, Irish Ashley, Purtill Duncan, Cooney Julian, Shaw Peter, Tey Siok-Keen, Hunt Stewart, Subramonia Pillai Elango, John George, Ng Michelle, Ramachandran Shanti, Hopkins Peter, Chambers Daniel, Campbell Scott, Francis Ross, Isbel Nicole, Marlton Paula, Reddiex Hilary, Matthews Katherine K, Voogt Meggie, Panikkar Archana, Beagley Leone, Rehan Sweera, Best Shannon, Raju Jyothy, Le Texier Laetitia, Crooks Pauline, Solomon Matthew, Lekieffre Lea, Srihari Sriganesh, Smith Corey, Khanna Rajiv. Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years.. Nature communications. 2024. DOI: 10.1038/s41467-024-54595-2.

Предметные рубрики MeSH

HumansImmunotherapy, AdoptiveT-LymphocytesMaleFemaleRetrospective StudiesMiddle AgedAdultCompassionate Use TrialsAgedAustraliaNew ZealandYoung AdultViral LoadVirus DiseasesImmunocompromised HostBK VirusAdolescentHerpesvirus 4, Human
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