Pediatric dermatology · 2003
Harlequin baby with ecthyma gangrenosum.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Duan Siyu, Wei Yiyi, Ding Zhuoyu, Pan Chaomin, Yang Li, Gu Yan, Wang Xinke
Аннотация
BACKGROUND: The metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most common causes of chronic and abnormal liver function tests globally. The relationship between metabolic MASLD and gastrointestinal tumors (GI) remains controversial.
METHODOLOGY: We conducted a systematic review based on a protocol registered with PROSPERO (CRD42024590389). PubMed, Cochrane Library, Web of Science, and Embase were systematically searched until November 2025, Quality assessment and data extraction were performed by two investigators, and the hazard ratios and their corresponding 95% confidence intervals were combined using Stata for data analysis.
RESULTS: A total of 29 studies were included, we found that MASLD were related to colorectal polyps (I 2 = 62.7, HR = 1.42, 95% CI [1.22-1.66]), colorectal cancer (I 2 = 82.8%, HR = 1.22, 95% CI [1.16-1.29]), p < 0.001) and esophagus cancer (I 2 =88.4, HR = 1.14, 95% CI [1.05-1.24], p < 0.001), gastric cancer (I 2 = 88, HR = 1.18, 95% CI [1.1-1.26]), cholangiocarcinoma (I 2 = 73.7, HR = 1.26, 95% CI [1.1 7-1. 36], P < 0.001) and gallbladder cancer (I 2 = 56.1, HR = 1.41, 95% CI [1.03-1.92], P < 0.001). Factors like follow-up time, study methods and countries contributed to heterogeneity of studies. Lastly, incidence rates (IR) and prognosis of GI cancer in patients with MASLD were highly correlated.
CONCLUSION: We conclude that there is a significant association and prognosis between MASLD and gastrointestinal tumors. Further studies should focus on prospective studies and mechanistic insights.
METHODOLOGY: We conducted a systematic review based on a protocol registered with PROSPERO (CRD42024590389). PubMed, Cochrane Library, Web of Science, and Embase were systematically searched until November 2025, Quality assessment and data extraction were performed by two investigators, and the hazard ratios and their corresponding 95% confidence intervals were combined using Stata for data analysis.
RESULTS: A total of 29 studies were included, we found that MASLD were related to colorectal polyps (I 2 = 62.7, HR = 1.42, 95% CI [1.22-1.66]), colorectal cancer (I 2 = 82.8%, HR = 1.22, 95% CI [1.16-1.29]), p < 0.001) and esophagus cancer (I 2 =88.4, HR = 1.14, 95% CI [1.05-1.24], p < 0.001), gastric cancer (I 2 = 88, HR = 1.18, 95% CI [1.1-1.26]), cholangiocarcinoma (I 2 = 73.7, HR = 1.26, 95% CI [1.1 7-1. 36], P < 0.001) and gallbladder cancer (I 2 = 56.1, HR = 1.41, 95% CI [1.03-1.92], P < 0.001). Factors like follow-up time, study methods and countries contributed to heterogeneity of studies. Lastly, incidence rates (IR) and prognosis of GI cancer in patients with MASLD were highly correlated.
CONCLUSION: We conclude that there is a significant association and prognosis between MASLD and gastrointestinal tumors. Further studies should focus on prospective studies and mechanistic insights.