Current medical imaging · 2026
Early Differentiation of Prostatic Intraepithelial Neoplasia via Multiparametric MRI Combined with PSA-derived Parameters.
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Zou Guannan, Liu Jingyan, Zhong Huanhuan, Zhang Heng, Zhu Yuhui, Xie Nanai, Wang Minghua, Li Xingzhi, Ma Wanling
Аннотация
BACKGROUND: Prostatic intraepithelial neoplasia (PIN) is a precancerous lesion. Early differentiation of PIN is very important for the prevention of PIN occurrence and malignization.
OBJECTIVES: To differentiate prostatic intraepithelial neoplasia (PIN) via multiparametric MRI (mpMRI) combined with prostate-specific antigen (PSA)-derived parameters.
MATERIALS AND METHODS: From March 2022 to June 2024, 47 males, including 39 with benign prostatic hyperplasia (BPH) and 8 with PIN, were enrolled. All patients underwent prostatic mpMRI. The apparent diffusion coefficients (ADC), Ktrans, kep, ve, initial area under curve (iAUC), and PI-RADS score were derived from mpMRI. The parameters between PIN and BPH were compared via Student's t test or Mann-Whitney U test. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy.
RESULTS: The ADC value of PIN was significantly greater than that of BPH (0.912 vs. 0.806 × 10-3 mm2/s, P=0.035). The tPSA, fPSA, and PSA density (PSAD) of PIN were significantly lower than those of BPH (6.715 vs. 11.640 ng/mL, P=0.008; 1.427 vs. 2.109 ng/mL, P=0.042; 0.095 vs. 0.158 ng/mL2, P=0.010; respectively). The AUC of tPSA was slightly greater than those of PSAD, ADC, and fPSA (0.801 > 0.792 > 0.724 > 0.716) in differentiating PIN from BPH. When the tPSA was ≤ 8.47 ng/mL, the highest sensitivity (87.5%) and negative predictive value (96.8%) were observed in differentiating PIN from BPH. When the ADC and PSA-derived parameters were combined, the highest specificity (94.9%) was acquired in differentiating PIN from BPH. ADC (OR=0.120, P = 0.043) and PSAD (OR=0.056, P = 0.005) were independent risk predictors for differentiating PIN from BPH.
DISCUSSION: ADC derived from mpMRI combined with PSA-derived parameters exhibit enormous potential for differentiating PIN from BPH.
CONCLUSIONS: ADC and PSA-derived parameters can distinguish PIN from BPH. The ADC value combined with tPSA can achieve the highest diagnostic efficiency in detecting PIN. The ADC may function as a potential biomarker to differentiate precancerous lesions of the prostate.
OBJECTIVES: To differentiate prostatic intraepithelial neoplasia (PIN) via multiparametric MRI (mpMRI) combined with prostate-specific antigen (PSA)-derived parameters.
MATERIALS AND METHODS: From March 2022 to June 2024, 47 males, including 39 with benign prostatic hyperplasia (BPH) and 8 with PIN, were enrolled. All patients underwent prostatic mpMRI. The apparent diffusion coefficients (ADC), Ktrans, kep, ve, initial area under curve (iAUC), and PI-RADS score were derived from mpMRI. The parameters between PIN and BPH were compared via Student's t test or Mann-Whitney U test. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy.
RESULTS: The ADC value of PIN was significantly greater than that of BPH (0.912 vs. 0.806 × 10-3 mm2/s, P=0.035). The tPSA, fPSA, and PSA density (PSAD) of PIN were significantly lower than those of BPH (6.715 vs. 11.640 ng/mL, P=0.008; 1.427 vs. 2.109 ng/mL, P=0.042; 0.095 vs. 0.158 ng/mL2, P=0.010; respectively). The AUC of tPSA was slightly greater than those of PSAD, ADC, and fPSA (0.801 > 0.792 > 0.724 > 0.716) in differentiating PIN from BPH. When the tPSA was ≤ 8.47 ng/mL, the highest sensitivity (87.5%) and negative predictive value (96.8%) were observed in differentiating PIN from BPH. When the ADC and PSA-derived parameters were combined, the highest specificity (94.9%) was acquired in differentiating PIN from BPH. ADC (OR=0.120, P = 0.043) and PSAD (OR=0.056, P = 0.005) were independent risk predictors for differentiating PIN from BPH.
DISCUSSION: ADC derived from mpMRI combined with PSA-derived parameters exhibit enormous potential for differentiating PIN from BPH.
CONCLUSIONS: ADC and PSA-derived parameters can distinguish PIN from BPH. The ADC value combined with tPSA can achieve the highest diagnostic efficiency in detecting PIN. The ADC may function as a potential biomarker to differentiate precancerous lesions of the prostate.