Solid Pseudopapillary Neoplasm of the Pancreas in an Adolescent: An Uncommon Finding.

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor in children with low malignant potential. It predominantly affects adolescent females and is frequently diagnosed incidentally. We report the case of an 11-year-old girl presenting with acute abdominal pain, fever, vomiting, and anorexia. Physical examination and initial ultrasound were inconclusive. Cross-sectional imaging via computed tomography (CT) and magnetic resonance imaging (MRI) revealed a large, heterogeneous mass in the pancreatic tail. Laboratory evaluation, including tumor markers, was unremarkable. She was managed initially with antibiotics for suspected inflammatory complications. After stabilization, she underwent laparoscopic spleen-preserving distal pancreatectomy. Immunohistochemical staining was positive for beta (β)-catenin, CD56, cyclin D1, and synaptophysin, and negative for chromogranin. No regional lymph node metastases were found (pT3N0M0). SPN, though rare in children, should be considered in the differential diagnosis of pancreatic masses. Surgical resection offers an excellent prognosis. Immunohistochemistry, particularly β-catenin staining, is essential for diagnosis.