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Nature genetics · 2019

Genome-wide association study identifies 30 loci associated with bipolar disorder.

СтатьяМетаанализResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Stahl Eli A, Breen Gerome, Forstner Andreas J, McQuillin Andrew, Ripke Stephan, Trubetskoy Vassily, Mattheisen Manuel, Wang Yunpeng, Coleman Jonathan R I, Gaspar Héléna A, de Leeuw Christiaan A, Steinberg Stacy, Pavlides Jennifer M Whitehead, Trzaskowski Maciej, Byrne Enda M, Pers Tune H, Holmans Peter A, Richards Alexander L, Abbott Liam, Agerbo Esben, Akil Huda, Albani Diego, Alliey-Rodriguez Ney, Als Thomas D, Anjorin Adebayo, Antilla Verneri, Awasthi Swapnil, Badner Judith A, Bækvad-Hansen Marie, Barchas Jack D, Bass Nicholas, Bauer Michael, Belliveau Richard, Bergen Sarah E, Pedersen Carsten Bøcker, Bøen Erlend, Boks Marco P, Boocock James, Budde Monika, Bunney William, Burmeister Margit, Bybjerg-Grauholm Jonas, Byerley William, Casas Miquel, Cerrato Felecia, Cervantes Pablo, Chambert Kimberly, Charney Alexander W, Chen Danfeng, Churchhouse Claire, Clarke Toni-Kim, Coryell William, Craig David W, Cruceanu Cristiana, Curtis David, Czerski Piotr M, Dale Anders M, de Jong Simone, Degenhardt Franziska, Del-Favero Jurgen, DePaulo J Raymond, Djurovic Srdjan, Dobbyn Amanda L, Dumont Ashley, Elvsåshagen Torbjørn, Escott-Price Valentina, Fan Chun Chieh, Fischer Sascha B, Flickinger Matthew, Foroud Tatiana M, Forty Liz, Frank Josef, Fraser Christine, Freimer Nelson B, Frisén Louise, Gade Katrin, Gage Diane, Garnham Julie, Giambartolomei Claudia, Pedersen Marianne Giørtz, Goldstein Jaqueline, Gordon Scott D, Gordon-Smith Katherine, Green Elaine K, Green Melissa J, Greenwood Tiffany A, Grove Jakob, Guan Weihua, Guzman-Parra José, Hamshere Marian L, Hautzinger Martin, Heilbronner Urs, Herms Stefan, Hipolito Maria, Hoffmann Per, Holland Dominic, Huckins Laura, Jamain Stéphane, Johnson Jessica S, Juréus Anders, Kandaswamy Radhika, Karlsson Robert, Kennedy James L, Kittel-Schneider Sarah, Knowles James A, Kogevinas Manolis, Koller Anna C, Kupka Ralph, Lavebratt Catharina, Lawrence Jacob, Lawson William B, Leber Markus, Lee Phil H, Levy Shawn E, Li Jun Z, Liu Chunyu, Lucae Susanne, Maaser Anna, MacIntyre Donald J, Mahon Pamela B, Maier Wolfgang, Martinsson Lina, McCarroll Steve, McGuffin Peter, McInnis Melvin G, McKay James D, Medeiros Helena, Medland Sarah E, Meng Fan, Milani Lili, Montgomery Grant W, Morris Derek W, Mühleisen Thomas W, Mullins Niamh, Nguyen Hoang, Nievergelt Caroline M, Adolfsson Annelie Nordin, Nwulia Evaristus A, O'Donovan Claire, Loohuis Loes M Olde, Ori Anil P S, Oruc Lilijana, Ösby Urban, Perlis Roy H, Perry Amy, Pfennig Andrea, Potash James B, Purcell Shaun M, Regeer Eline J, Reif Andreas, Reinbold Céline S, Rice John P, Rivas Fabio, Rivera Margarita, Roussos Panos, Ruderfer Douglas M, Ryu Euijung, Sánchez-Mora Cristina, Schatzberg Alan F, Scheftner William A, Schork Nicholas J, Shannon Weickert Cynthia, Shehktman Tatyana, Shilling Paul D, Sigurdsson Engilbert, Slaney Claire, Smeland Olav B, Sobell Janet L, Søholm Hansen Christine, Spijker Anne T, St Clair David, Steffens Michael, Strauss John S, Streit Fabian, Strohmaier Jana, Szelinger Szabolcs, Thompson Robert C, Thorgeirsson Thorgeir E, Treutlein Jens, Vedder Helmut, Wang Weiqing, Watson Stanley J, Weickert Thomas W, Witt Stephanie H, Xi Simon, Xu Wei, Young Allan H, Zandi Peter, Zhang Peng, Zöllner Sebastian, eQTLGen Consortium, BIOS Consortium, Adolfsson Rolf, Agartz Ingrid, Alda Martin, Backlund Lena, Baune Bernhard T, Bellivier Frank, Berrettini Wade H, Biernacka Joanna M, Blackwood Douglas H R, Boehnke Michael, Børglum Anders D, Corvin Aiden, Craddock Nicholas, Daly Mark J, Dannlowski Udo, Esko Tõnu, Etain Bruno, Frye Mark, Fullerton Janice M, Gershon Elliot S, Gill Michael, Goes Fernando, Grigoroiu-Serbanescu Maria, Hauser Joanna, Hougaard David M, Hultman Christina M, Jones Ian, Jones Lisa A, Kahn René S, Kirov George, Landén Mikael, Leboyer Marion, Lewis Cathryn M, Li Qingqin S, Lissowska Jolanta, Martin Nicholas G, Mayoral Fermin, McElroy Susan L, McIntosh Andrew M, McMahon Francis J, Melle Ingrid, Metspalu Andres, Mitchell Philip B, Morken Gunnar, Mors Ole, Mortensen Preben Bo, Müller-Myhsok Bertram, Myers Richard M, Neale Benjamin M, Nimgaonkar Vishwajit, Nordentoft Merete, Nöthen Markus M, O'Donovan Michael C, Oedegaard Ketil J, Owen Michael J, Paciga Sara A, Pato Carlos, Pato Michele T, Posthuma Danielle, Ramos-Quiroga Josep Antoni, Ribasés Marta, Rietschel Marcella, Rouleau Guy A, Schalling Martin, Schofield Peter R, Schulze Thomas G, Serretti Alessandro, Smoller Jordan W, Stefansson Hreinn, Stefansson Kari, Stordal Eystein, Sullivan Patrick F, Turecki Gustavo, Vaaler Arne E, Vieta Eduard, Vincent John B, Werge Thomas, Nurnberger John I, Wray Naomi R, Di Florio Arianna, Edenberg Howard J, Cichon Sven, Ophoff Roel A, Scott Laura J, Andreassen Ole A, Kelsoe John, Sklar Pamela, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium

Аннотация

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты