Biology open · 2026
SPSP-1 is a sperm protein required for C. elegans hermaphrodite sperm production and embryogenesis.
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Murat Darline, Nagorski Margaret, Kwah Ji Kent, Pfeiffer Shannon, Duker Nancy, Döring Frank, Jaramillo-Lambert Aimee
Аннотация
Development requires the fusion of two gametes each with a haploid complement of DNA and the necessary components (RNA, proteins, organelles) needed for early cellular processes and divisions. The C. elegans paternal-effect embryonic lethal gene, spe-11, is one of the few known sperm components required for normal development. Sperm-provided SPE-11 forms a complex with the oocyte protein OOPS-1 at fertilization that mediates egg activation events. In this manuscript, we identified SPSP-1, a sperm protein that is associated with SPE-11. We found that SPSP-1 co-localizes with SPE-11 during spermatogenesis and in spermatids. SPSP-1 does not appear to play a role in egg activation like SPE-11. However, SPSP-1 is required to produce normal levels of hermaphrodite sperm and for wild-type levels of embryonic viability.