Kyobu geka. The Japanese journal of thoracic surgery · 2026
[Strategy for Thymoma With Pure Red Cell Aplasia].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Kochi Hiroyuki, Izumi Nobuhiro, Suzuki Satoshi, Inoue Hidetoshi, Tsukioka Takuma, Soh Junichi
Аннотация
BACKGROUND: Pure red cell aplasia( PRCA) is a rare hematologic disorder that can be associated with thymoma. Optimal management requires both tumor resection and immunosuppressive therapy, but the clinical course varies among patients.
CASE PRESENTATION: A 76-year-old woman was referred to our hospital for evaluation of severe anemia and was diagnosed with thymoma accompanied by PRCA. After receiving a blood transfusion, she underwent robot-assisted thymothymectomy. Histopathological examination revealed a type AB thymoma [World Health Organization (WHO) classification] of Masaoka stageⅠ. Two weeks postoperatively, cyclosporine A (CyA) therapy was initiated. The patient has subsequently maintained a favorable clinical course without the need for additional blood transfusions for 15 months.
CONCLUSION: We report a rare case of thymoma-associated PRCA successfully managed with surgery followed by CyA administration. This case highlights the importance of combined surgical and immunosuppressive therapy for achieving long-term transfusion independence in patients with thymoma-associated PRCA.
CASE PRESENTATION: A 76-year-old woman was referred to our hospital for evaluation of severe anemia and was diagnosed with thymoma accompanied by PRCA. After receiving a blood transfusion, she underwent robot-assisted thymothymectomy. Histopathological examination revealed a type AB thymoma [World Health Organization (WHO) classification] of Masaoka stageⅠ. Two weeks postoperatively, cyclosporine A (CyA) therapy was initiated. The patient has subsequently maintained a favorable clinical course without the need for additional blood transfusions for 15 months.
CONCLUSION: We report a rare case of thymoma-associated PRCA successfully managed with surgery followed by CyA administration. This case highlights the importance of combined surgical and immunosuppressive therapy for achieving long-term transfusion independence in patients with thymoma-associated PRCA.