[Correlation of occlusion pressure with sedation in non-neurocritical patients].

BACKGROUND

Mechanical ventilation is used in conjunction with sedation, which is titrated with clinical scales based on the therapeutic objective. It is difficult to find a reliable marker of respiratory drive in critically ill patients, so determining the correlation between the depth of sedation and airway occlusion pressure at 100 milliseconds (P0.1) would help titrate the depth of sedation and regulate respiratory drive.

OBJECTIVE

To determine whether P0.1 correlates with the depth of sedation measured with a clinical RASS scale and the bispectral index.

MATERIAL AND

METHODS

A prospective cohort study was conducted with non-neurocritical patients undergoing mechanical ventilation from April 1, 2023, to September 30, 2023, in a tertiary care hospital in Mexico City.

RESULTS

229 patients were included. Pearson's correlation was applied comparing the simultaneously measured BIS with the P0.1, finding a correlation of 0.64 with a p < 0.001. The correlation of this with RASS was 0.43, with propofol -0.18, with benzodiazepines -0.036, with buprenorphine -0.25, and with dexmedetomidine 0.051.

CONCLUSION

There was a stronger correlation of P0.1 with the BIS compared with the RASS and the doses of the drugs used. It could be used for titrating sedation in non-neurocritical patients.