[Pathomorphological criteria for the differential diagnosis of leukoplakia and chronic recurrent papillomavirus cystitis].

INTRODUCTION

According to the literature of recent years, there has been an increased interest in non-oncological diseases of the bladder, between which differential diagnostics have to be carried out in order to determine a plan for the diagnosis and treatment of patients with these nosologies. There are often certain difficulties in the differential diagnosis of some forms of viral cystitis and leukoplakia

OBJECTIVE

to determine pathomorphological criteria for the differential diagnosis of leukoplakia and chronic recurrent papillomavirus cystitis.

MATERIALS AND

METHODS

The prospective study included 85 sexually active patients aged 20-45 years, who were divided into two groups depending on the etiological factor. Patients of group I (n=70) - with chronic recurrent cystitis (CRC) of papillomavirus (PV) etiology, group II (n=15) - with leukoplakia. All patients were examined in accordance with the recommendations of the European Association of Urology (EAU) and the Russian Society of Urology (ROU); an additional endoscopic examination of the bladder (cystoscopy) was performed, followed by a morphological examination of the bladder biopsy.

RESULTS

A morphological examination of biopsy tissue in all patients of group I revealed koilocytic transformation of the urothelium combined with non-keratinizing metaplasia of the urothelium, and in patients of group II, in all cases, keratinizing metaplasia of the urothelium with hyperkeratosis was detected.

CONCLUSION

Morphological examination is the gold standard in differential leukoplakia and chronic recurrent papillomavirus cystitis.