Stage IIIC Bilateral Dysgerminoma in 46,XY Swyer Syndrome: Preventing Malignancy Through Early Endocrine Evaluation of Primary Amenorrhea.

Primary amenorrhea requires systematic endocrine evaluation before empirical hormonal therapy. In adolescents with hypergonadotropic hypogonadism, prompt karyotype analysis is essential to identify 46,XY complete gonadal dysgenesis (Swyer syndrome), enabling timely prophylactic gonadectomy, preventing gonadal malignancy, and improving endocrine, reproductive, and long-term clinical outcomes.