Progress towards a Group B streptococcal vaccine - where are we now?

The global burden of Group B streptococcal (GBS) disease remains high and an effective vaccine in pregnancy is an unmet public health need. GBS vaccines have been in development for decades, with earlier work providing evidence of immunogenicity and safety but not resulting in a licensed product. More recently, two vaccine candidates have reached advanced stages of clinical development. This article reviews the progress towards a GBS vaccine, the challenges that lie ahead and how they might be overcome.