Nature medicine · 2019
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Risal Sanjiv, Pei Yu, Lu Haojiang, Manti Maria, Fornes Romina, Pui Han-Pin, Zhao Zhiyi, Massart Julie, Ohlsson Claes, Lindgren Eva, Crisosto Nicolas, Maliqueo Manuel, Echiburú Barbara, Ladrón de Guevara Amanda, Sir-Petermann Teresa, Larsson Henrik, Rosenqvist Mina A, Cesta Carolyn E, Benrick Anna, Deng Qiaolin, Stener-Victorin Elisabet
Аннотация
How obesity and elevated androgen levels in women with polycystic ovary syndrome (PCOS) affect their offspring is unclear. In a Swedish nationwide register-based cohort and a clinical case-control study from Chile, we found that daughters of mothers with PCOS were more likely to be diagnosed with PCOS. Furthermore, female mice (F0) with PCOS-like traits induced by late-gestation injection of dihydrotestosterone, with and without obesity, produced female F1-F3 offspring with PCOS-like reproductive and metabolic phenotypes. Sequencing of single metaphase II oocytes from F1-F3 offspring revealed common and unique altered gene expression across all generations. Notably, four genes were also differentially expressed in serum samples from daughters in the case-control study and unrelated women with PCOS. Our findings provide evidence of transgenerational effects in female offspring of mothers with PCOS and identify possible candidate genes for the prediction of a PCOS phenotype in future generations.