McCune-Albright syndrome associated with acromegaly and bipolar affective disorder.

McCune-Albright syndrome is a rare disorder caused by an activating mutation in the gene (GNAS1) encoding the subunit of the G protein. This syndrome is characterized by polyostotic fibrous dysplasia, café-au-lait pigmentation, and multiple endocrine hyperfunction. A 29-year-old male with polyostotic fibrous dysplasia, café-au-lait pigmentations, and pituitary adenoma is presented in this report. The patient had accompanying bipolar affective disorder, which might have been caused by the underlying genetic abnormality.