The Journal of asthma : official journal of the Association for the Care of Asthma · 2026
Allergic rhinitis duration and small-airway dysfunction in adolescents without asthma: a cross-sectional impulse oscillometry study.
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Polat Gulce, Sahin Cihangir, Koksal Zeynep Gulec, Mercan Adnan, Atar Bese Simge, Tuncerler Gulten, Torer Nur, Cevik Ozge, Kurt Omurlu Imran, Ozen Boluk Selime, Uysal Pinar, Erge Duygu
Аннотация
OBJECTIVE: Allergic rhinitis (AR) is a mucosal inflammatory disease increasingly viewed within a united-airway framework, yet whether lower-airway function deteriorates as AR persists in adolescents without asthma remains unclear. We used impulse oscillometry (IOS) to examine the relationship between AR duration and small-airway function, and examined serum endocan (endothelial cell-specific molecule-1, ESM-1), whose relationship to airway function in AR is unknown, as a candidate systemic biomarker.
METHODS: Forty treatment-naïve, aeroallergen-sensitized adolescents (12-17 years) with AR and 37 non-atopic controls of comparable age and sex underwent IOS, serum endocan measurement (ELISA, enzyme-linked immunosorbent assay), specific immunoglobulin E (IgE) testing, and skin prick testing. Symptoms were scored on a visual analog scale, and core IOS indices were expressed as age- and sex-adjusted z-scores.
RESULTS: No IOS parameter differed between patients and controls. However, longer AR duration was associated with higher total-airway resistance (zR5 r = 0.323, p = 0.042) and lower reactance (zX5 r = -0.502, p < 0.001); specific IgE also increased with age, duration, and severity. Serum endocan levels were similar in patients and controls (median 200.8 vs. 218.8 ng/mL; p = 0.517) and, within the AR group, did not correlate with severity, persistence, or IOS parameters.
CONCLUSIONS: Greater oscillometric small-airway dysfunction was associated with longer AR duration, supporting the use of IOS to assess lower-airway function in adolescents with long-standing AR. Serum endocan did not distinguish patients from controls; because paired airway sampling was not performed, whether any endocan signal in AR is confined to the airway mucosa remains speculative.
METHODS: Forty treatment-naïve, aeroallergen-sensitized adolescents (12-17 years) with AR and 37 non-atopic controls of comparable age and sex underwent IOS, serum endocan measurement (ELISA, enzyme-linked immunosorbent assay), specific immunoglobulin E (IgE) testing, and skin prick testing. Symptoms were scored on a visual analog scale, and core IOS indices were expressed as age- and sex-adjusted z-scores.
RESULTS: No IOS parameter differed between patients and controls. However, longer AR duration was associated with higher total-airway resistance (zR5 r = 0.323, p = 0.042) and lower reactance (zX5 r = -0.502, p < 0.001); specific IgE also increased with age, duration, and severity. Serum endocan levels were similar in patients and controls (median 200.8 vs. 218.8 ng/mL; p = 0.517) and, within the AR group, did not correlate with severity, persistence, or IOS parameters.
CONCLUSIONS: Greater oscillometric small-airway dysfunction was associated with longer AR duration, supporting the use of IOS to assess lower-airway function in adolescents with long-standing AR. Serum endocan did not distinguish patients from controls; because paired airway sampling was not performed, whether any endocan signal in AR is confined to the airway mucosa remains speculative.