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Войти в исследования Frontiers in endocrinology · 2026
Overexpression of FGFR1 in AgRP neurons protects against obesity and improves glucose homeostasis.
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Shookster Daniel, Martin Ahjanelle, Gunn Madison, O'Connell Shea, Huang Hu
Аннотация
BACKGROUND: The rising prevalence of metabolic disorders highlights the need to identify targetable pathways. Although hypothalamic AgRP neuron signaling influences energy balance, the beneficial role of fibroblast growth factor receptor 1 (FGFR1) within these neurons remains incompletely understood.
METHODS: We employed an AAV-mediated CRISPR/Cas9 activation system to achieve AgRP neuron-specific overexpression of FGFR1 in adult mice. Metabolic phenotypes were assessed during high-fat diet (HFD) feeding, and mechanistic insights were gained using GT1-7 hypothalamic cells.
RESULTS: FGFR1 overexpression in AgRP neurons attenuated high-fat diet (HFD)-induced weight gain and improved glucose tolerance, effects that were associated with reduced energy intake. Mechanistically, FGFR1 overexpression correlated with increased FOXO1 phosphorylation and reduced AgRP mRNA expression, suggesting a potential FGFR1-FOXO1 regulatory axis.
CONCLUSION: These findings identify a contributory role for AgRP neuronal FGFR1 signaling in modulating metabolic outcomes under HFD conditions and suggest that this pathway may represent a potential avenue for further investigation in the context of obesity and diabetes.
METHODS: We employed an AAV-mediated CRISPR/Cas9 activation system to achieve AgRP neuron-specific overexpression of FGFR1 in adult mice. Metabolic phenotypes were assessed during high-fat diet (HFD) feeding, and mechanistic insights were gained using GT1-7 hypothalamic cells.
RESULTS: FGFR1 overexpression in AgRP neurons attenuated high-fat diet (HFD)-induced weight gain and improved glucose tolerance, effects that were associated with reduced energy intake. Mechanistically, FGFR1 overexpression correlated with increased FOXO1 phosphorylation and reduced AgRP mRNA expression, suggesting a potential FGFR1-FOXO1 regulatory axis.
CONCLUSION: These findings identify a contributory role for AgRP neuronal FGFR1 signaling in modulating metabolic outcomes under HFD conditions and suggest that this pathway may represent a potential avenue for further investigation in the context of obesity and diabetes.