Beyond goal directed perfusion: Individualizing O2-delivery to O2-consumption.

Goal directed perfusion (GDP) aims to maintain an O2 delivery above 270-300 ml/min/m2, during cardiopulmonary bypass. This strategy decreases the incidence of postoperative acute kidney injury. We first developed a simple physiological hypothesis that explained why maintaining an indexed DO2 above 280-300 ml/min/m2 could optimize organ protection during bypass, then we propose to tailor the O2 supply to patient real time VO2 as an individualized strategy, to optimize supply to metabolism need.