Pathologica · 2003
DNA ploidy in cervical lesions assessed by computed image analysis: relation to histopathology.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Shirata N K, Zerbini M C Nogueira, Longatto Filho A, de Mello E Sobroza, Arias V, Nonogaki S, Alves V Avancini Ferreira
Аннотация
OBJECTIVE: To assess the different patterns of DNA nuclear content in cervical intraepithelial neoplasia.
STUDY DESIGN: DNA nuclear content patterns (DNA ploidy) were assessed in 82 paraffin embedded samples diagnosed as chronic cervicitis CIN 1, CIN 2 and CIN 3 by image analysis using the CAS200 BD System. These results were compared to the consensus diagnosis of two pathologists. The chi-square test was used to evaluate the results of classificatory variables (CIN 1, CIN 2 and CIN 3).
RESULTS: Aneuploidy was found in 86% of CIN 3; 59% CIN 2; 26%% CIN 1. All samples classified as chronic cervicitis were diploid.
CONCLUSIONS: The DNA nuclear content was found to parallel the three grades of the histological WHO classification. Aneuploidy was strongly associated with the high-grade lesions; the detection of a subset aneuploidy of low grade lesions would suggest a indicate closer follow-up of these cases.
STUDY DESIGN: DNA nuclear content patterns (DNA ploidy) were assessed in 82 paraffin embedded samples diagnosed as chronic cervicitis CIN 1, CIN 2 and CIN 3 by image analysis using the CAS200 BD System. These results were compared to the consensus diagnosis of two pathologists. The chi-square test was used to evaluate the results of classificatory variables (CIN 1, CIN 2 and CIN 3).
RESULTS: Aneuploidy was found in 86% of CIN 3; 59% CIN 2; 26%% CIN 1. All samples classified as chronic cervicitis were diploid.
CONCLUSIONS: The DNA nuclear content was found to parallel the three grades of the histological WHO classification. Aneuploidy was strongly associated with the high-grade lesions; the detection of a subset aneuploidy of low grade lesions would suggest a indicate closer follow-up of these cases.