The role of miRNA-17-3p, oxidative stress, and trace elements in the pathogenesis of preeclampsia.

INTRODUCTION AND AIMS: Preeclampsia (PE) is a multifactorial pregnancy disorder marked by hypertension and organ dysfunction. Emerging evidence suggests miRNAs, as epigenetic regulators, play a critical role. Since miR-17-3p is implicated in oxidative stress and vascular function, and considering the known roles of trace elements in redox homeostasis, we hypothesized that their interplay contributes to PE pathogenesis. This study examines the relationship between miRNA-17-3p expression, oxidative stress markers, and trace element levels (zinc and copper) in PE patients.

METHODS

A case-control study included 140 pregnant women (70 with PE and 70 controls). Placental tissue and serum samples were analyzed for miRNA-17-3p expression, oxidative stress markers [superoxide dismutase (SOD), total antioxidant capacity (TAC), total oxidative status (TOS)], and trace element levels. Statistical analyses explored associations among these variables.

RESULTS

miRNA-17-3p expression was significantly elevated in the placental tissue and serum of PE patients (P < 0.001). Serum zinc levels significantly decreased, while copper levels increased in the patient group (P < 0.05). SOD activity and TAC levels were reduced, whereas TOS was elevated in PE patients (P < 0.05).

CONCLUSION

miRNA-17-3p is significantly dysregulated in PE, accompanied by increased oxidative stress and disrupted trace element balance. These findings provide insights into potential mechanisms and novel therapeutic targets for managing PE.