Na[18F]F PET/CT quantification in spondyloarthritis: comparative evaluation of SUV normalization approaches.

BACKGROUND

Sodium [18F]Fluoride Positron Emission Tomography (Na[18F]F PET) is a promising imaging biomarker for evaluating bone metabolism in spondyloarthritis (SpA) and other bone affecting diseases. Accurate quantification of tracer uptake is essential for assessing disease activity and treatment response. This study aimed to determine optimal simplified metrics for Na[18F]F uptake and evaluate their performance compared to net influx rate (Ki).

RESULTS

A prospective study included 54 SpA patients undergoing Na[18F]F PET/CT scans at baseline and after 12 weeks of therapy. Dynamic PET in combination with venous blood sampling was analyzed to derive kinetic parameters, including Ki in 43 scans that included pathological uptake in the dynamic field of view. Semi-quantitative standardized uptake values (SUVs) corrected body weight (BW), lean body mass (LBM), body surface area (BSA) and skeletal volume (SV) were compared and correlations between Ki and SUVs were assessed cross-sectionally and longitudinally. Based on analysis of the blood sample data, there was a significant difference between SUV corrected for BW between patients who weighted more and less than 85 kg (p < 0.01 at all sample moments). When LBM or SV was used, this difference disappeared (p > 0.05). There was a significant correlation between Ki and various SUV-metrics, with SUVpeak-LBM at 25-30 min yielding the highest correlation both cross-sectionally (R2 = 0.77, p < 0.01), and longitudinally (R2 = 0.54, p < 0.01).

CONCLUSIONS

Na[18F]F uptake quantification of lesions in the axial skeleton of SpA patients can be performed cross-sectionally and longitudinally with simplified uptake measures, particularly SUVpeak, normalized using LBM or SV. This offers a more reliable approach to evaluating disease activity and treatment responses compared to BW.