Медицинская библиотека · Fetal and pediatric pathology · 2019

Can Ki67 and Caspase Predict Molar Progression?

Nagib Reham M, M A Zaki Marwa, Wageh Alaa, Abdelrazik Mahmoud

СтатьяПеревод в очереди

Аннотация

Background

A clinical risk score has been introduced into the management of persistent trophoblastic disease to allow individualized therapy. However, this risk scoring system lacks histopathologic predictors. The hypothesis is that there are prognostic histological markers that might contribute to the detection of those cases that will have persistent trophoblastic disease.

Methods

Trophoblastic proliferation and apoptosis were investigated via immunohistochemical expression of Ki67 and caspase in 24 complete moles. These were divided into two groups; group A represented cases with persistent trophoblastic disease and group B represented cases with no persistent trophoblastic disease. Sections were immunostained with a monoclonal antibody for both caspase and Ki67.

Results

No statistically significant difference was found between either group regarding the expression of Ki67 or caspase.

Conclusion

Neither proliferation or apoptosis are reliable markers for progression of molar pregnancy.

Для цитирования: Nagib Reham M, M A Zaki Marwa, Wageh Alaa, Abdelrazik Mahmoud. Can Ki67 and Caspase Predict Molar Progression?. Fetal and pediatric pathology. 2019. DOI: 10.1080/15513815.2019.1608607.

Предметные рубрики MeSH

Adult Apoptosis Biomarkers, Tumor Caspases Cell Proliferation Disease Progression Female Gestational Trophoblastic Disease Humans Hydatidiform Mole Ki-67 Antigen Pregnancy Trophoblasts Uterine Neoplasms

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.