Prognostic potential of serum CA125 and pregnant markers in threatened abortion.

To predict the outcome of patients with threatened abortion at an early stage of gestation is clinically important. CA125 and nine hormones associated with pregnancy were measured from 4 to 12 weeks of gestation in 256 pregnant women with threatened abortion. The nine hormones were: serum human chorionic gonadotropin beta-subunit, serum progesterone, serum cortisol, serum human placental lactogen, serum estrone, serum estradiol, serum estriol, urine human chorionic gonadotropin and urine estrogen. Ultrasonographic examination was also performed from 6 to 12 weeks of gestation. Of the 256 patients, 90 aborted and 166 carried to term. We found that changes in CA125 in patients with threatened abortion differed from those of the nine hormones. At 4 to 8 weeks of gestation the mean value for serum CA125 in patients with successful outcome was significantly higher than that in patients who aborted. Although ultrasonographic examination is effective after 8 weeks of gestation, serum CA125 measurement is useful in predicting early abortion.