Frontiers in immunology · 2026
Comparison of chimeric mouse-human and humanized anti-CD25 monoclonal antibodies for steroid-refractory acute graft-versus-host disease.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Zheng Xinhui, Zhou Yunxia, Zheng Yawei, Lu Ni, Cao Yigeng, Zhai Weihua, Wei Jialin, Yang Donglin, Zhang Rongli, Pang Aiming, Feng Sizhou, Han Mingzhe, Jiang Erlie, Chen Xin
Аннотация
INTRODUCTION: Steroid-refractory acute graft-versus-host disease (SR-aGVHD) represents a severe and persistent complication that can arise following allogeneichematopoietic stem cell transplantation (allo-HSCT). This study aimed toassess the effectiveness and safety of basiliximab compared with those of a humanized anti-CD25 monoclonal antibody (xenopax) in the treatment of SR-aGVHD in patients who underwent allo-HSCT.
METHODS: This retrospective trial included 32 patients diagnosed with SR-aGVHD who were administered xenopax at 1 mg/kg on days 1, 4, and 8, and weekly thereafter until aGVHD severity was reduced to below grade 2. A historical cohort of 37 patients received basiliximab, which is a chimeric mouse-human anti-CD25 antibody.
RESULTS: The overall response (OR) rate on day 28 was not significantly different between The xenopax and basiliximab groups, with rates of 82% and 72%, respectively (p=0.57). Additionally, no differences were observed between the groups regarding the safety profile. The 1-year overall survival (OS) and non-relapse mortality (NRM) rates in the xenopax and basiliximab cohorts were 64% versus 40% (p=0.06) and 45% versus 48% (p=0.46), respectively.
DISCUSSION: In conclusion, no significant differences were observed in efficacy or adverse events between chimeric mouse-human and humanized anti-CD25 monoclonal antibodies for the treatment of SR-aGVHD. Further studies with larger cohorts are necessary to validate these findings.
METHODS: This retrospective trial included 32 patients diagnosed with SR-aGVHD who were administered xenopax at 1 mg/kg on days 1, 4, and 8, and weekly thereafter until aGVHD severity was reduced to below grade 2. A historical cohort of 37 patients received basiliximab, which is a chimeric mouse-human anti-CD25 antibody.
RESULTS: The overall response (OR) rate on day 28 was not significantly different between The xenopax and basiliximab groups, with rates of 82% and 72%, respectively (p=0.57). Additionally, no differences were observed between the groups regarding the safety profile. The 1-year overall survival (OS) and non-relapse mortality (NRM) rates in the xenopax and basiliximab cohorts were 64% versus 40% (p=0.06) and 45% versus 48% (p=0.46), respectively.
DISCUSSION: In conclusion, no significant differences were observed in efficacy or adverse events between chimeric mouse-human and humanized anti-CD25 monoclonal antibodies for the treatment of SR-aGVHD. Further studies with larger cohorts are necessary to validate these findings.
Предметные рубрики MeSH
HumansGraft vs Host DiseaseInterleukin-2 Receptor alpha SubunitFemaleAdultMaleAnimalsRetrospective StudiesMiddle AgedBasiliximabHematopoietic Stem Cell TransplantationImmunosuppressive AgentsMiceTreatment OutcomeAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAcute DiseaseSteroidsYoung AdultAdolescentTransplantation, HomologousDrug Resistance