Tear film parameters in females with thyroid eye disease and diabetes: an observational study.

OBJECTIVES

To assess different tear film parameters in female patients with thyroid eye disease and diabetes using a single portable device.

METHODS

The observational study was conducted at the College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia, from January 12 to April 28, 2022, and comprised women patients with thyroid eye disease in group A, women patients with diabetes in group B, and healthy controls in group C. The sample size was determined with a confidence level of 80% and a significance of 0.05. The participants were subjected first to the Ocular Surface Disease Index, followed by non-invasive tear breakup time, tear meniscus height, and lipid layer pattern tests using EasyTear View+. Data was analysed using SPSS 22.

RESULTS

Of the 120 women, 40(33.33%) with mean age 40.4±11.7 years were in group A, 40(33.33%) with mean age 39.8±12.2 years in group B, and 40(33.33%) controls with mean age 37.2±9.5 years were in group C. Significant differences were found in the median values of Ocular Surface Disease Index, non-invasive tear breakup time, tear meniscus height and lipid layer pattern in group C compared to groups A and B p<0.00. The non-invasive tear breakup time score was strongly correlated in group B with the tear meniscus height score (r=0.559, p<0.001. The lipid layer pattern analysis indicated that grade A was predominant in groups A (35%) and B (45%), while grade D was typical in group C (40%).

CONCLUSIONS

Women with thyroid eye disease and diabetes had significantly thin lipid layers and lower tear meniscus height and non-invasive tear breakup time than healthy subjects.