Gut microbiota as a therapeutic target in sepsis-induced multi-organ dysfunction: a review.

Sepsis and the resulting multiple organ dysfunction carry a high mortality rate, and effective treatment remains lacking owing to the condition's heterogeneity. The translocation of gut microbiota plays an essential role in the occurrence and development of sepsis and organ dysfunction. Uncontrolled inflammatory responses in sepsis, together with antibiotic use during treatment, lead to gut microbiota translocation. This in turn promotes sepsis progression and organ dysfunction by altering microbial metabolite production and causing immune dysregulation. Drawing on literature from databases such as PubMed and Web of Science, this review summarizes the interactions between intestinal microbiota translocation, sepsis, and organ dysfunction, aiming to identify new targets for the prevention and treatment of sepsis.