Pharmacology · 2009
Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice.
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Girard Philippe, Pansart Yannick, Coppé Marie-Claude, Niedergang Betty, Gillardin Jean-Marie
Аннотация
BACKGROUND/AIMS: Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT(3) receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol).
METHODS: The present study was designed to explore the effect of 3 serotonin 5-HT(3) receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests.
RESULTS: Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test.
CONCLUSION: These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.
METHODS: The present study was designed to explore the effect of 3 serotonin 5-HT(3) receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests.
RESULTS: Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test.
CONCLUSION: These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.