Medicine · 2025
Amlodipine overdose rescued with extracorporeal membrane oxygenation: A case report.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Ding Hong, Wang Hui, Wang Zi-Yan, Liu Yuan-Zheng, Zhang Kun
Аннотация
RATIONALE: Amlodipine, a calcium channel blocker, is widely prescribed for managing hypertension through vascular smooth muscle relaxation. However, severe amlodipine toxicity can lead to profound hypotension and refractory shock, often unresponsive to conventional treatments.
PATIENT CONCERNS: In this report, we reported a 32-year-old female case of amlodipine overdose who was admitted to our hospital on March 1, 2024, due to intentionally ingesting approximately 84 tablets of amlodipine (5 mg each).
DIAGNOSES: Patient was diagnosed with amlodipine overdose and refractory shock.
INTERVENTION: Patient was treated with extracorporeal membrane oxygenation (ECMO), invasive mechanical ventilation, and continuous renal replacement therapy.
OUTCOMES: On March 7, the patient was successfully weaned off ECMO and discharged on March 15, 2024. During postoperative follow-up, the lung CT scan showed complete resolution of intrapulmonary exudates.
LESSONS: The case prompts that early initiation of ECMO, following the failure of conventional medical interventions, was pivotal in stabilizing the patient's hemodynamics, offering a promising alternative in the management of severe calcium channel blocker toxicity.
PATIENT CONCERNS: In this report, we reported a 32-year-old female case of amlodipine overdose who was admitted to our hospital on March 1, 2024, due to intentionally ingesting approximately 84 tablets of amlodipine (5 mg each).
DIAGNOSES: Patient was diagnosed with amlodipine overdose and refractory shock.
INTERVENTION: Patient was treated with extracorporeal membrane oxygenation (ECMO), invasive mechanical ventilation, and continuous renal replacement therapy.
OUTCOMES: On March 7, the patient was successfully weaned off ECMO and discharged on March 15, 2024. During postoperative follow-up, the lung CT scan showed complete resolution of intrapulmonary exudates.
LESSONS: The case prompts that early initiation of ECMO, following the failure of conventional medical interventions, was pivotal in stabilizing the patient's hemodynamics, offering a promising alternative in the management of severe calcium channel blocker toxicity.