Reproductive physiological amelioration of BPA - induced toxicity by resveratrol: Sperm quality preservation, DNA damage mitigation, and testicular protection.

OBJECTIVE

Aim: The object of the present study aimed to investigate the impact of Bisphenol A on the fragmentation, and histopathological changes, and evaluating the protective effects of resveratrol against Bisphenol A.

PATIENTS AND

METHODS

Materials and

Methods

The study used forty adults male Wistar rats were that randomly divided into four groups: a control group, a Bisphenol A group administered at 50 mg/kg/day, a resveratrol group at 50 mg/kg/day, and a Bisphenol + resveratrol group at the same dosages for 60 consecutive days. The blood and tissue samples were collected for evaluating the sperm parameters, DNA integrity, Luteinizing hormone, Testosterone hormone, total antioxidant capacity, and histopathological section.

RESULTS

Results

The results showed that Bisphenol A exposure causes significantly disrupted in sperm motility, concentration, morphology, and DNA integrity, with severe histopathological change in testicular tissue and causes significantly increasing in luteinizing hormone and decreased testosterone levels. In contrast, the results illustrated the resveratrol play as protective effects by conserved the sperm quality, testicular histopathology and reducing DNA fragmentation.

CONCLUSION

Conclusions

The Bisphenol A-induced significantly increased in oxidative stress while resveratrol play significant protection against Bisphenol A which that induced testicular damage. The present finds proved that resveratrol is a potential therapeutic agent that can be used as an intervention against chemical substances in the environment and preserve the fertility.