Медицинская библиотека · Clinical laboratory · 2025

A Case of Falsely Low Serum Creatinine by Enzymatic Method due to Immunoglobulin M Paraprotein Interference.

Xiaoling Chen, Ziyan Ye, Jinbiao Wu, Ying Zhao

Клинический случайСтатьяПеревод в очереди

Аннотация

BACKGROUND

We report a case of negative serum creatinine (SCr) value due to the interference of immunoglobulin M (IgM) paraprotein.

METHODS

We measured SCr using dilution patterns of 1:10, 1:20, 1:50 on Roche Cobas®c702 analyzer. Then the patient's serum was precipitated 1:1 with polyethylene glycol (PEG) 6000 and was measured for SCr. Additionally, we used the VITROS® 350 Dry Chemistry platform to measure SCr.

RESULTS

The correct SCr results could not be obtained by normal and dilution patterns, and there were abnormal reaction curves. Reliable SCr results were obtained by PEG precipitation or dry chemical determination.

CONCLUSIONS

The negative Scr value by enzymatic method was caused by the IgM paraprotein. Looking at the SCr reaction curve was an easy way to observe the presence of IgM paraprotein interference.

Для цитирования: Xiaoling Chen, Ziyan Ye, Jinbiao Wu, Ying Zhao. A Case of Falsely Low Serum Creatinine by Enzymatic Method due to Immunoglobulin M Paraprotein Interference.. Clinical laboratory. 2025. DOI: 10.7754/clin.lab.2025.250359.

Предметные рубрики MeSH

Humans Immunoglobulin M Creatinine Paraproteins False Negative Reactions Male Female Biomarkers

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