Characteristics, pathophysiology, and management of Galassi III arachnoid cysts: a scoping review protocol.

OBJECTIVE

This scoping review aims to map the existing evidence on Galassi III arachnoid cysts and identify knowledge gaps in the current literature.

INTRODUCTION

Galassi III arachnoid cysts are rare intracranial lesions characterized by significant midline displacement and associated with space-occupying effects. Despite their rarity, they have higher intervention rates than other types, yet optimal management remains unclear. Understanding their prevalence, pathophysiology, clinical characteristics, natural history, management strategies, and outcomes is critical for enhancing research on evidence-based management strategies aimed to improve patient care.

ELIGIBILITY CRITERIA: This review will include clinical studies and review articles investigating patients with Galassi III arachnoid cysts. Studies should address the prevalence, pathophysiology, physical characteristics, natural history, presenting symptoms, treatment strategies, and/or outcomes associated with Galassi III arachnoid cysts. Studies published in English or Spanish will be included.

METHODS

This scoping review will follow JBI methodology and will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) guidelines. A comprehensive search will be conducted in the PubMed, Scopus, and Web of Science Core Collection databases using a structured electronic search strategy developed in collaboration with a research librarian. Gray literature will be incorporated by searching clinical trial registries for studies involving patients with Galassi III arachnoid cysts. No publication date restrictions will be applied. The selection process will involve 3 steps, and relevant data from included studies will be extracted using a standardized form. Quantitative and qualitative methods will be employed to synthesize the data. Results will be presented in graphic, tabular, and narrative formats.

REVIEW REGISTRATION: OSF https://osf.io/evbqk/overview.