Occupational exposure to chlorinated and petroleum solvents and mycosis fungoides.

OBJECTIVE

To evaluate the potential association between occupational exposure to chlorinated and petroleum solvents and mycosis fungoides (MF).

METHODS

A questionnaire on lifetime job history was administered to 100 patients diagnosed with MF and 2846 controls. Odds ratios (ORs) were calculated as the measure of the association between exposure to each specific solvent and MF.

RESULTS

In the total sample and in men, cases and controls did not differ in relation to exposure to any of the solvents studied. In women, an association with MF was seen for the highest level of estimated exposure to perchloroethylene (OR = 11.38; 95% confidence interval: 1.04 to 124.85) and for exposure less than the median to kerosene/fuel/gasoil (OR = 8.53; 95% confidence interval: 1.11 to 65.62).

CONCLUSIONS

These results do not provide conclusive evidence that exposure to solvents may increase risk of MF because they were not found in men.