MedElevator
Войти в исследования The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
Trends, variation, and predictors of coronary angiography in potential cardiac organ donors.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bhowmik A C, Wayda B, Weng Y, Zhang S, Neidlinger N, Khush K K
Аннотация
PURPOSE: Performance of invasive coronary angiography (ICA) to screen for coronary artery disease (CAD) in younger potential heart donors is discretionary and thus may vary across regions. We examined the variation, predictors, and outcomes of ICA in potential heart donors in the United States.
METHODS: Using the Scientific Registry of Transplant Recipients (SRTR), our cohort included brain-dead potential heart donors from 2018 to 2023. Older donors (> 50 years for men, > 55 for women) were excluded; the remainder were stratified as young (< 35) or middle-aged. We further stratified by "low" or "high" CAD risk; the latter was defined by a history of diabetes or ≥ 2 other non-age risk factors. We characterized temporal and geographic variation and predictors of ICA using multivariable logistic regression. We also characterized the prevalence of significant CAD (any ≥ 50% stenosis) among donors who received ICA.
RESULTS: Of 11,897 young and 8,936 middle-aged donors, 2,443 (20.5%) and 5,272 (59.0%), respectively, received ICA. Coronary angiogram performance increased over time and was highest in New England for both groups. Among CAD risk factors, diabetes (in young donors only), age, smoking, and cocaine use were predictive of ICA utilization. Among young low-risk, young high-risk, middle-aged low-risk, and middle-aged high-risk donors who received coronary angiography, 1%, 2%, 3%, and 7%, respectively, had significant CAD.
CONCLUSIONS: ICA is performed in 20% of young potential heart donors, varies widely by region, and rarely identifies significant CAD in young or otherwise low-risk donors. Standardized protocols are needed to rationalize its use.
METHODS: Using the Scientific Registry of Transplant Recipients (SRTR), our cohort included brain-dead potential heart donors from 2018 to 2023. Older donors (> 50 years for men, > 55 for women) were excluded; the remainder were stratified as young (< 35) or middle-aged. We further stratified by "low" or "high" CAD risk; the latter was defined by a history of diabetes or ≥ 2 other non-age risk factors. We characterized temporal and geographic variation and predictors of ICA using multivariable logistic regression. We also characterized the prevalence of significant CAD (any ≥ 50% stenosis) among donors who received ICA.
RESULTS: Of 11,897 young and 8,936 middle-aged donors, 2,443 (20.5%) and 5,272 (59.0%), respectively, received ICA. Coronary angiogram performance increased over time and was highest in New England for both groups. Among CAD risk factors, diabetes (in young donors only), age, smoking, and cocaine use were predictive of ICA utilization. Among young low-risk, young high-risk, middle-aged low-risk, and middle-aged high-risk donors who received coronary angiography, 1%, 2%, 3%, and 7%, respectively, had significant CAD.
CONCLUSIONS: ICA is performed in 20% of young potential heart donors, varies widely by region, and rarely identifies significant CAD in young or otherwise low-risk donors. Standardized protocols are needed to rationalize its use.