CEN case reports · 2025
Human immunodeficiency virus-associated nephropathy mainly due to cellular variant of focal segmental glomerulosclerosis.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Tanimizu Hikaru, Sawa Naoki, Sekine Akinari, Oba Yuki, Yamanouchi Masayuki, Hasegawa Eiko, Suwabe Tatsuya, Hoshino Junichi, Kinowaki Keiichi, Kono Kei, Ohashi Kenichi, Kanetsuna Yukiko, Honda Kazuho, Joh Kensuke, Yamaguchi Yutaka, Wada Takehiko, Ubara Yoshifumi
Аннотация
A 45-year-old man with a low titer of hepatitis B virus (HBV) was diagnosed with nephrotic syndrome. A subsequent test for human immunodeficiency virus (HIV) was positive. Kidney biopsy revealed some signs of collapsing variant of focal segmental glomerulosclerosis (FSGS), but the predominant finding was a cellular variant of FSGS. Two years after receiving tenofovir, urine protein became negative, and the patient was finally diagnosed with HIV-associated nephropathy. Collapsing variant of FSGS is considered typical of HIV-related nephropathy, but the cellular variant of FSGS in this patient represents another type. The cause of many FSGSs is often never identified, making cause-based treatment difficult. This case demonstrates that identification of the cause of FSGS can lead to treatment of FSGS.