Placental Pathology and Its Importance in Preterm Infants.

OBJECTIVE

We evaluated what placental pathologies were associated with adverse preterm births.

MATERIALS AND

METHODS

Placental findings, classified according to the Amsterdam criteria, were correlated with infant outcomes. The fetal vascular lesions, inflammatory responses other than histological chorioamnionitis (HCA), and placentas with combined maternal vascular malperfusion (MVM) and HCA were excluded.

RESULTS

A total of 772 placentas were evaluated. MVM was present in 394 placentas, HCA in 378. Early neonatal sepsis, retinopathy of prematurity, necrotizing enterocolitis, and neonatal death occurred more often in the MVM-only group than HCA-only group. The frequency of bronchopulmonary dysplasia (BPD) was 38.6% in the HCA-only group, and it was 20.3% in the MVM-only group (p < 0.001). HCA was the most important independent risk factor for BPD (OR 3.877, 95% CI 2.831-5.312).

CONCLUSION

Inflammation in the placenta influences fetal and neonatal outcomes. HCA is an independent risk factor for BPD.