Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2026
Chronological Changes in Causes of Death in Brain Death Donors: A 7-Year Analysis in the Tuscany Region.
СтатьяНазвание и аннотация: Перевод в очереди
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Lazzeri Chiara, Bombardi Marco, Bonizzoli Manuela, Cultrera Daniele, Procissi Arianna Precisi O, Santini Lara Entani, Lo Pane Paolo, Girardi Eufrasio, Peris Adriano
Аннотация
OBJECTIVES: During the past 5 years, donation from donors after circulatory death has increased by 4 % worldwide, whereas donation from donors after brain death has remained unchanged. Organs from circulatory death donors are known to be less performative than organs from brain death donors, and the pool of brain death donors remains the main source of organ transplants in many countries. Chronological changes in the criteria for brain death in donors have occurred in many countries.
MATERIALS AND METHODS: We describe chronological changes in causes of death in 2877 brain death donors consecutively assessed in Tuscany from 2015 to 2024. Two different periods were considered: 2015 to 2019 (period 1 ) and 2021 to 2024 (period 2 ).
RESULTS: Significant increases in postanoxic encephalopathy (P = .037 ) and in "other causes " (P = .002 ) were observed in period 2 versus period 1. A significant decrease in traumatic brain injury (P = .002 ) was also detected. The number of utilized donors significantly increased in period 2 with an increase in liver transplants and kidney transplants.
CONCLUSIONS: Our investigation of a large cohort of brain death donors assessed in the Tuscany region from 2015 to 2024 showed dynamic changes in the etiologies of brain death, mainly with an increase in postanoxic encephalopathy and a reduction in ischemic stroke. Nevertheless, utilization rate increased recently, with a rise in liver transplants and kidney transplants. Our data strongly suggest the importance of transplant authorities to monitor epidemiological changes in causes of death in brain death donors, to identify areas for potential improvement.
MATERIALS AND METHODS: We describe chronological changes in causes of death in 2877 brain death donors consecutively assessed in Tuscany from 2015 to 2024. Two different periods were considered: 2015 to 2019 (period 1 ) and 2021 to 2024 (period 2 ).
RESULTS: Significant increases in postanoxic encephalopathy (P = .037 ) and in "other causes " (P = .002 ) were observed in period 2 versus period 1. A significant decrease in traumatic brain injury (P = .002 ) was also detected. The number of utilized donors significantly increased in period 2 with an increase in liver transplants and kidney transplants.
CONCLUSIONS: Our investigation of a large cohort of brain death donors assessed in the Tuscany region from 2015 to 2024 showed dynamic changes in the etiologies of brain death, mainly with an increase in postanoxic encephalopathy and a reduction in ischemic stroke. Nevertheless, utilization rate increased recently, with a rise in liver transplants and kidney transplants. Our data strongly suggest the importance of transplant authorities to monitor epidemiological changes in causes of death in brain death donors, to identify areas for potential improvement.