Turning perfusion into repair through ferroptosis blockade.

By identifying graft ferroptosis as a druggable vulnerability, Veeckmans et al. show that FXT-001 intercepts lipid-radical injury during machine perfusion and improves liver and lung graft function. This work supports rather than proves machine perfusion as a therapeutic window for preimplantation graft repair, a concept that now requires postimplantation validation.