Flavasperfurans A and B, Two New Asperfuran Derivatives From the Marine-Derived Fungus Aspergillus flavus.

Marine microorganisms represent a prolific reservoir of chemically diverse natural products endowed with considerable therapeutic potential. In the present study, two new asperfurans (1 and 2) and 23 known compounds (3-25) were obtained from Aspergillus flavus, a marine fungus isolated from a water sample of the Western Pacific. Their structures were determined by detailed analysis of the 1D and 2D NMR, HRESIMS, and NMR calculations with DP4+ probability analysis, as well as ECD calculations. Asperfuran (3) exhibited potent inhibitory activity against renin-angiotensin system-selective lethal 3 (RSL3)-induced ferroptosis with a half maximal effective concentration (EC50) value of 0.81 µM.