Translationally Controlled Tumor Protein (TCTP/HRF) in Animal Venoms.

Proteins from TCTP/HRF family were identified as venom toxins of spiders from different genus. We have found a TCTP toxin in the venom gland of Loxosceles intermedia, a venomous spider very common in South Brazil. TCTP from L. intermedia, named LiTCTP, was cloned, produced in a heterologous prokaryotic system, and the recombinant toxin was biochemically characterized. Our results point that LiTCTP is involved in the inflammatory events of Loxocelism, the clinical signs triggered after Loxosceles sp. bite, which include intense inflammatory reaction at the bite site followed by local necrosis. TCTP toxins were also identified in spiders from different genus. There are very few articles about TCTP toxins in other venomous animals in the literature, although a NCBI database search on the protein sequences reveals TCTP on snake's venom glands transcriptomic and genomic studies. Studies on TCTP as a venom toxin are very few and its biological role as a venom component in prey capture is still unknown.