Indian journal of pediatrics · 2009
Endothelin-1 and leptin as markers of intrauterine growth restriction.
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Nezar Mohamed Al-Shahat, el-Baky Azza Mohammad Abd, Soliman Othman Al-Said, Abdel-Hady Hesham Al-Said, Hammad Ayman Mohammad, Al-Haggar Mohammad Saleh
Аннотация
OBJECTIVE: To explore the role of endothelin-1 (ET-1) and leptin in intrauterine growth restriction (IUGR) among preeclamptic and non-pre-eclamptic women.
METHODS: Forty three patients with a pregnancy complicated by IUGR, 23 cases with severe pre-eclampsia and 20 cases of non-pre-eclamptic were enrolled. Control group comprised 15 cases with uncomplicated pregnancy. Blood samples from umbilical artery and maternal venous blood were collected at the time of delivery for analysis of ET-1 and leptin levels. Mode of delivery, birth weight and Apgar score were also recorded.
RESULTS: The mean maternal and fetal ET-1 level was significantly higher in pregnancies complicated by IUGR than in control group. The mean maternal leptin level was significantly higher in pre-eclamptic patients when compared to non-preeclamptic and control groups. Mean fetal leptin level was significantly lower in patients compared to control; however, when fetal leptin corrected to fetal weight, it was insignificantly different in the both groups. E-mail: m. alhaggar@yahoo.co.uk.
CONCLUSION: Maternal plasma ET-1 and leptin correlate with the degree of fetal growth restriction originating from deterioration of placental function. Maternal plasma leptin and ET-1 levels may reflect deterioration in fetal growth.
METHODS: Forty three patients with a pregnancy complicated by IUGR, 23 cases with severe pre-eclampsia and 20 cases of non-pre-eclamptic were enrolled. Control group comprised 15 cases with uncomplicated pregnancy. Blood samples from umbilical artery and maternal venous blood were collected at the time of delivery for analysis of ET-1 and leptin levels. Mode of delivery, birth weight and Apgar score were also recorded.
RESULTS: The mean maternal and fetal ET-1 level was significantly higher in pregnancies complicated by IUGR than in control group. The mean maternal leptin level was significantly higher in pre-eclamptic patients when compared to non-preeclamptic and control groups. Mean fetal leptin level was significantly lower in patients compared to control; however, when fetal leptin corrected to fetal weight, it was insignificantly different in the both groups. E-mail: m. alhaggar@yahoo.co.uk.
CONCLUSION: Maternal plasma ET-1 and leptin correlate with the degree of fetal growth restriction originating from deterioration of placental function. Maternal plasma leptin and ET-1 levels may reflect deterioration in fetal growth.
Предметные рубрики MeSH
AdultAnalysis of VarianceBiomarkersBirth WeightCase-Control StudiesChi-Square DistributionEndothelin-1Enzyme-Linked Immunosorbent AssayFemaleFetal Growth RetardationGestational AgeHumansInfant, NewbornLeptinLinear ModelsMaternal AgePre-EclampsiaPredictive Value of TestsPregnancyPregnancy OutcomePrenatal CareProbabilityReference ValuesSensitivity and SpecificitySeverity of Illness IndexUltrasonography, PrenatalYoung Adult