Effects of ciprofol on hemodynamics and cerebral protection in patients undergoing meningioma resection.

BACKGROUND

Meningiomas are common intracranial tumors. Surgery remains the primary therapy. The purpose of this study was to investigate the effects of ciprofol on hemodynamics and cerebral protection in patients undergoing meningioma resection.

METHODS

Seventy-eight patients with intracranial tumor were selected and divided into a control group and a ciprofol group (Group A) of 39 cases each. The Group A was induced and maintained with ciprofol, while the control group was induced and maintained with propofol. The heart rate (HR) and arterial blood pressure were recorded before anesthesia (T0), immediately before intubation (T1), 3 minutes after intubation (T2), immediately after complete tumor resection (T3) and the end of surgery (T4). The levels of neuron specific enolase (NSE) and S100β were determined by enzyme-linked immunosorbent assay in the preoperative and postoperative 24 hours. The eye-opening time, extubation time, and the occurrence of postoperative adverse reactions were recorded.

RESULTS

There were significant differences in the arterial blood pressure and HR between the 2 groups at T1 and T2 (P < .05), while there were no significant differences in the arterial blood pressure and HR at other time points. The eye-opening time was longer in the Group A than the control group (23.1 ± 4.5 vs 20.9 ± 3.2 minutes, P = .014). However, the incidence of injection site pain and hypotension during induction of anesthesia was obviously decreased in the Group A (10% vs 54%, P < .001; 95% vs 59%, P < .001, respectively).The levels of S100 β and NSE was higher in the Group A than the control group at postoperative 24 hours, there were significant differences in postoperative S100 β and NSE between the 2 groups (1.69 ± 0.44 vs 1.49 ± 0.27 µg/L, P = .017; 17.9 ± 3.5 vs 16.2 ± 2.9, P = .021, respectively).

CONCLUSION

This study showed that ciprofol could maintain hemodynamics more stable in patients undergoing meningioma resection, but it was not superior to propofol in terms of cerebral protection.